Three-Dimensional Imaging-Based Radiobiological Dosimetry

Three-dimensional imaging-based radiobiological dosimetry.

Targeted radionuclide therapy holds promise as a new treatment for cancer. Advances in imaging are making it possible for researchers to evaluate the spatial distribution of radioactivity in tumors and normal organs over time. Matched anatomical imaging, such as combined single-photon emission computed tomography/computed tomography and positron emission tomography/computed tomography, has also...

Three-Dimensional Radiobiological Dosimetry (3D-RD): Application of Radiobiological Modeling to Patient-Specific, 3-D Imaging-based Internal Dosimetry

Three-dimensional gel dosimetry for dose volume histogram verification in compensator-based IMRT

Background: Some tissues in human body are radiobiologically different from water and these inhomogeneity must be considered in dose calculation in order to achieve an accurate dose delivery. Dose verification in complex radiation therapy techniques, such as intensity‐modulated radiation therapy (IMRT) calls for volumetric, tissue equivalent and energy independent dosimeter. The purpose of this...

Three dimensional radiation dosimetry using polymer gels

The use of polymer gels to record radiation dose distributions in three dimensions was first proposed in 1992 as a proof-of-principle [1]. The accuracy of these early polymer gel dosimeters and scanning methods was not sufficient for most clinical applications [2]. Since then, several efforts were made to increase the accuracy and precision of both the physical gel dosimeter and the scanning te...

Radiobiological Model-Based Comparison of Three-Dimensional Conformal and Intensity-Modulated Radiation Therapy Plans for Nasopharyngeal Carcinoma

Introduction: Radiobiological modeling of radiotherapy plans are used for treatment plan comparisons. The current study aimed to compare the three-dimensional conformal radiation therapy (3DCRT) and intensity-modulated radiation therapy (IMRT) plans for nasopharyngeal cancer using radiobiological modeling. Materials and Methods: This study was conducted on 10 patients with nasopharyngeal carci...